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[(and)-247.5(all)-249.3(relevant)-247.9(laws)-249.2(of)-241.9(the)-251.6(country)-245.9(where)-248.6(the)-245.2(recruiting)-251.2(sites)-244.3(were)]TJ
0 -1.1065 TD
[(located,)-274(including)-269.3(but)-261.8(not)-268.1(limited)-271.5(to,)-265.2(the)-270.5(relevant)-266.9(privacy)-273.6(and)-266.5(data)]TJ
0 -1.1128 TD
[(protection)-280.2(laws)-274.5(and)-272.8(regulations)-274.6(\(the)-272.7()54.8(Privacy)-274.3(Law)57(\),)-272.7(the)-276.9(relevant)]TJ
T*
[(laws)-205(and)-197(regulations)-198.7(on)-195(the)-201(use)-198.2(of)-197.6(human)-199.5(materials,)-202.2(and)-197(all)-198.7(relevant)]TJ
T*
[(guidance)-431(relating)-432.9(to)-426.7(clinical)-436.7(studies)-426.7(from)-430.4(time)-429.4(to)-426.7(time)-435.7(in)-426.7(force)]TJ
0 -1.1065 TD
[(including,)-525.2(but)-527.4(not)-521(limited)-530.8(to,)-524.4(the)-523.5(International)-528(Conference)-526.9(on)]TJ
0 -1.1128 TD
[(Harmonisation)-387.9(\(ICH\))-380.1(Harmonised)-387.7(Tripartite)-381.5(Guideline)-382.5(for)-383.1(Good)]TJ
T*
[(Clinical)-211.4(Practice)-217.3(\(CPMP/ICH/135/95;)-207()54.8(ICH)-213.6(GCP)56(\))-212.9(and)-203.3(the)-213.6(World)]TJ
T*
[(Medical)-550(Association)-542(Declaration)-547.1(of)-539.1(Helsinki)-546.2(entitled)-541.8()54.8(Ethical)]TJ
0 -1.1065 TD
[(Principles)-330.5(for)-319.9(Medical)-328.7(Research)-324.1(Involving)-322.4(Human)-323(Subjects.)49.5()-318.3(In-)]TJ
0 -1.1128 TD
[(formed)-248.5(consent)-246.9(by)-245.6(the)-245.2(patients)-248.1(and/or)-246.4(the)-251.6(legal)-244.4(representative/next)]TJ
T*
[(of)-513.8(kin)-508.4(was)-517.6(obtained,)-511.4(accordingly)-512(to)-508.9(the)-517.1(local)-509.9(legislations,)-511.2(for)]TJ
T*
[(all)-432.6(patients)-437.8(recruited)-433.4(in)-426.7(the)-434.9(core)-429.1(data)-436.9(set)-429.8(of)-431.6(CENTER-TBI)-434.4(and)]TJ
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[(documented)-275.5(in)-274.9(the)-270.5(e-CRF.)-279.1(Ethical)-272.5(approval)-273.1(was)-277.3(obtained)-274.5(for)-269.3(each)]TJ
0 -1.1128 TD
[(recruiting)-257.5(site.)-252.9(The)-253.7(list)-251.6(of)-254.5(sites,)-253.6(ethical)-249.8(committees,)-259.6(approval)-254.2(num-)]TJ
T*
[(bers,)-228.5(and)-228.6(approval)-222.5(dates)-228.9(can)-224.7(be)-229.1(found)-221.5(on)-226.6(the)-226.3(study)-224.1(website)-228.9(\(https://)]TJ
0 -1.1065 TD
(www.centertbi.eu/project/ethical-approval\).)Tj
/F8 1 Tf
0 -3.0729 TD
[(Treatment:)-334.8(Care)-336.2(pathway)]TJ
0 -1.2203 TD
[(and)-335.7(treatment)-335.5(characteristics)]TJ
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1.1128 -1.7514 TD
[(We)-281.6(analyzed)-281.7(the)-283.2(following)-279.1(care)-286.1(pathway)-280.6(variables:)]TJ
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0 -1.8084 TD
()Tj
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[(Secondary)-307.5(referral:)-305.8(dened)-304(as)-299.8(transfer)-304.8(from)-304(another)-305.2(hospital)]TJ
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[(to)-414(the)-416(study)-413.8(center)-409.3(\(vs.)-416.2(primary)-416.4(referral)]TJ
/F7 1 Tf
16.8822 0 TD
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/F4 1 Tf
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[(direct)-417.2(transfer)-412.3(to)]TJ
-17.5967 -1.2203 TD
[(the)-333.8(study)-337.9(hospital\).)]TJ
/F9 1 Tf
-.999 -1.2266 TD
()Tj
/F4 1 Tf
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T*
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/F9 1 Tf
-.999 -1.2267 TD
()Tj
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.999 0 TD
[(Discharge)-437.6(home:)-431.2(dened)-436.8(as)-432.6(discharge)-434.3(after)-435.3(the)-434.9(ER)-427.2(versus)]TJ
0 -1.2203 TD
[(discharge)-396.4(to)-388.7(other)-392.3(facility,)-395.6(hospital,)-394.1(high)-387.8(care)-393.6(unit,)-394.7(or)-387.3(ICU)]TJ
T*
[(and)-266.5(was)-264.7(analyzed)-269(only)-261.3(for)-263(patients)-267.1(with)-262.3(mTBI.)-270.9(Admission)-259.4(to)]TJ
T*
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0 -1.2266 TD
[(other)-386(facility,)-389.3(admission)-385(to)-382.4(the)-384.3(hospital)-384.8(or)-387.3(a)-387.6(high)-381.4(care)-387.3(unit)]TJ
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[(was)-327.9(analyzed)-325.9(for)-326.2(all)-325.1(patients)-324(and)-323.4(separately)-332.8(for)-319.9(hospitalized)]TJ
T*
[(patients)-336.7(with)-338.2(mTBI.)]TJ
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-.999 -1.2266 TD
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/F4 1 Tf
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0 -1.2203 TD
[(to)-508.9(general)-510(ward,)-502.5(other)-506.1(hospital,)-507.9(rehabilitation,)-510.6(home,)-506.4(and)]TJ
T*
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[(lyzed)-335.2(only)-337.2(for)-332.5(moderate/severe)-341.3(patients.)]TJ
/F9 1 Tf
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0 -1.2203 TD
[(hospital)-448(stay,)-451.2(and)-443.6(it)-449.7(was)-448(analyzed)-452.4(for)-446.3(all)-445.3(patients)-450.5(and)-443.6(for)]TJ
T*
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/F9 1 Tf
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/F4 1 Tf
.999 0 TD
[(Final)-367(discharge)-364.8(home:)-367.9(as)-363(nal)-369.8(discharge)-364.8(location,)-370(based)-364(on)]TJ
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[(discharge)-295.2(from)-291.3(the)-295.8(ER,)-291(ICU,)-290.3(and)-291.8(hospital)-296.3(\(vs.)-289.8(rehabilitation,)]TJ
T*
[(nursing)-333.2(home,)-335.7(or)-336.7(other)-335.4(hospital\).)]TJ
/F9 1 Tf
-.999 -1.2266 TD
()Tj
/F4 1 Tf
.999 0 TD
[(Final)-537.7(discharge)-541.8(to)-540.5(rehabilitation:)-536.5(as)-540.1(nal)-534.2(discharge)-541.8(loca-)]TJ
0 -1.2203 TD
[(tion,)-483.2(based)-477.8(on)-485.9(discharge)-478.6(from)-481(the)-479.2(ER,)-480.7(ICU,)-486.3(and)-481.5(hospital)]TJ
T*
[(\(vs.)-618.6(home,)-613.9(nursing)-611.4(home,)-620.2(or)-608.6(other)-619.9(hospital\).)-617.5(Final)-613.6(dis-)]TJ
0 -1.2266 TD
[(charge)-531.7(was)-530.2(analyzed)-534.6(for)-528.5(patients)-526.3(who)-533(survived)-531.1(until)-528.1(the)]TJ
0 -1.2203 TD
(discharge.)Tj
/F1 1 Tf
-30.1097 77.2217 TD
(2)Tj
46.8781 0 TD
(MIKOLIC)Tj
3.7052 .2213 TD
()Tj
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[(ET)-338.7(AL.)]TJ
ET
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[(As)-281.7(treatment)-286.6(characteristics,)-286.7(we)-283(analyzed:)]TJ
/F9 1 Tf
1.1128 -1.8336 TD
()Tj
/F4 1 Tf
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[(Pre-hospital)-313.2(intubation:)-308(dened)-316.6(as)-306.1(an)-311.3(intubated)-309.7(airway)-315.3(upon)]TJ
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[(arrival)-419.3(to)-407.7(the)-416(study)-413.8(hospital)-416.4(and)-411.9(was)-416.4(analyzed)-414.5(for)-414.7(patients)]TJ
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[(with)-338.2(moderate/severe)-335(TBI.)]TJ
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-.999 -1.2203 TD
()Tj
/F4 1 Tf
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/F9 1 Tf
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(38)Tj
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T*
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[(dead)-306.2(\(1\);)-303.9(vegetative)-308.6(s)2.5(tate)-302.3(\(2\);)-303.9(lo)]TJ
13.5121 0 TD
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[(wer)-302.2(s)2.8(evere)-308.3(d)3.9(isabili)6.2(ty)-305.9(\(3\);)-303.6(upper)]TJ
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[(severe)-308.5(di)6(sability)-306.1(\(4\);)-310.1(lower)-308.7(m).2(od)]TJ
13.4804 0 TD
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[(erate)-315.7(d)2.8(isabil)5.2(ity)-313.3(\(5\);)-317.3(upper)-309.6(mod-)]TJ
-13.4804 -1.1065 TD
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[(erate)-422.5(d)3.5(isabil)5.8(ity)-420.1(\(6\);)-417.8(lower)-416.4(g)-2.8(oo)]TJ
13.0189 0 TD
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[(d)-420.8(r).2(ecovery)-427.1(\(7\);)-424.8(and)-420.8(u)-3.5(pper)-417.1(good)]TJ
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T*
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[(qu)4.6(esti)6.9(on)4.6(naire)-434.1(o)4.6(r)-434.2(a)-427.7(teleph)4.6(on)4.6(e)-434.1(i).6(n)4.6(t).6(ervi)6.9(ew.)-428.7(A)1.3(pp)4.6(ro)4.6(ximately)-431.6(7)4.6(%)-433.8(o)4.6(f)]TJ
0 -1.1065 TD
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[(r)-14.8(e)-20.9(s)-13.3(p)-12.2(o)-18.5(n)-12.2(s)-19.7(e)-14.6(s)-304.2(w)-15.5(e)-14.6(r)-14.8(e)-305.4(b)-18.5(y)-303(a)-305.4(pr)-8(ox)-11.7(y)-296.7(alo)-11.3(ne)-14.1(,)-293.8(a)0(n)-7.8(d)-296.7(9%)-298.3(by)-302.5(a)-292.8(p)0(a)-14.1(t)0(i)-7.1(e)-8.2(nt)-300.2(an)-7.8(d)-296.7(p)0(r)-8(o)0(x)-11.7(y)]TJ
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[(t)-9.9(oge)-13.6(th)-9.4(e)-8.3(r)0(.)-245.3(T)0(h)-11.5(e)-242.2(c)-8.2(ate)-13.7(go)-11.7(ri)-12(es)-242.9()48.5()-8.4(ve)-7.8(ge)-14.1(tat)-15.3(iv)-9.4(e)-242.2(s)-7(ta)-11.8(te)-245.7(\(G)-11.3(OS)-7.2(E)-245.9(2)0(\))-7.9()48.5()-242.4(a)-8.2(nd)-245.6()48.5(lo)-11.5(w)-9.1(e)0(r)]TJ
T*
[(s)-7(e)-8.3(ve)-7.8(r)-8.4(e)-216.9(di)-9.4(s)-7(a)0(b)-7.8(i)-9.9(li)-7.1(ty)-224.3(\(G)-11.3(OS)-7.2(E)-220.6(3)0(\))-7.9()48.5()-217.1(w)-9.1(er)-10.4(e)-216.9(c)-8.2(om)-8.9(bi)-9.4(ne)-7.8(d,)-223.7(r)-8.4(e)0(s)-8.9(u)0(l)-9.4(t)-9.9(in)-9.4(g)-214.5(i)0(n)-224.3(a)-216.9(7-)-14.3(poi)-15.2(nt)]TJ
T*
[(or)-14.3(di)-9.4(na)-7.8(l)-288.1(s)-7(ca)-10.2(le)-11.8(.)]TJ
/F2 1 Tf
1.1128 -2.6367 TD
[(Return)-413.7(to)-412.6(work.)]TJ
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8.0301 0 TD
[(Return)-364.9(to)-357.1(work)-364.4(is)-358.3(assessed)-362.2(by)-359.4(a)-362.3(follow-up)]TJ
-9.1429 -1.1128 TD
[(questionnaire.)-468.6(Return)-466.1(to)-464.6(work)-465.5(represented)-470(post-injury)-468.3(return)-464(to)]TJ
T*
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0 -1.1065 TD
[(or)-292.5(hours.)-288.8(Not)-284.1(returning)-289.5(to)-287.6(work)-288.5(represented)-292.9(return)-293.2(to)-287.6(the)-289.5(previous)]TJ
0 -1.1128 TD
[(job)-344(or)-343.1(school)-339.8(activity)-345.8(at)-346.9(reduced)-341.6(level,)-342.1(sheltered)-349.8(employment,)-340.5(or)]TJ
T*
[(inability)-473.4(to)-470.9(work/go)-474.4(to)-470.9(school.)-469.2(Answers)-472.2(reecting)-473.7(changing)-472.8(or)]TJ
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[(searching)-282.6(for)-282(a)-280.1(job/school)-282.7(or)-279.8(being)-282.2(retired)-280.2(were)-287(not)-280.8(included.)]TJ
/F8 1 Tf
0 -2.643 TD
[(Post-concussion)-334.4(and)-335.7(mental)-331.5(health)-334.3(symptoms)]TJ
0 -1.2203 TD
[(at)-336.7(6)-333.2(months)]TJ
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1.1128 -1.8336 TD
[(Rivermead)-766.8(Post-Concussion)-767.7(Symptoms)-771.3(Questionnaire)]TJ
-1.1128 -1.2203 TD
(\(RPQ\).)Tj
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4.1162 0 TD
[(The)-291.6(RPQ)]TJ
6.7246 0 0 5.9768 130.6204 267.9873 Tm
(39)Tj
8.9663 0 0 8.9663 139.9747 264.0188 Tm
[(measures)-296.4(cognitive,)-293.6(somatic,)-289(and)-291.8(emotional)]TJ
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[(symptoms)-300.4(that)-299.4(are)-296.8(compared)-300.3(with)-293.9(the)-302.1(pre-injury)-297.9(level.)-297.9(It)-296.5(contains)]TJ
T*
[(16)-188.7(items)-189.8(that)-185.5(can)-186.7(be)-184.8(answered)-193.8(with)-186.4(0)]TJ
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14.5617 0 TD
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[(not)-185.9(experienced,)-187(1)]TJ
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7.4231 0 TD
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[(no)-188.7(more)]TJ
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[(of)-324.1(a)-324.4(problem)-319(\(than)-322.7(before)-323.3(the)-321.1(injury\),)-322.6(2)]TJ
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16.37 0 TD
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[(mild)-319.4(problem,)-321.9(3)]TJ
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(mod-)Tj
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[(erate)-447.7(problem,)-448.4(or)-437.9(4)]TJ
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8.3842 0 TD
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[(severe)-450.7(problem.)-442(Total)-444.1(score)]TJ
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12.1716 0 TD
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[(12)-441.6(\(treating)]TJ
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[(ratings)-276.4()54.8(no)-279.3(more)-272.2(of)-279.8(a)-273.8(problem)52()-274(a)0(s)-274.5(0)0(\))]TJ
6.7246 0 0 5.9768 196.3275 218.1543 Tm
(40)Tj
8.9663 0 0 8.9663 205.5117 214.1858 Tm
[(was)-277.3(considered)-275.7(indicative)]TJ
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[(of)-279.8(having)-281.7(increased)-285(PCS.)]TJ
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1.1128 -2.6367 TD
[(Patient)-824.5(Health)-825.9(Questionnaire)-829.8(\(PHQ-9\).)]TJ
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19.6516 0 TD
[(The)-772.2(PHQ-9)]TJ
6.7246 0 0 5.9768 292.1385 184.5354 Tm
(41)Tj
8.9663 0 0 8.9663 59.7543 170.5889 Tm
[(measures)-214.2(depression)-205(severity.)-211.7(It)-208(contains)-206.2(nine)-206.8(items)-208.7(using)-211.4(a)-204.3(4-point)]TJ
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[(Likert)-269.2(scale)-269.3(\(from)-261.8(0)]TJ
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8.2135 0 TD
(=)Tj
/F4 1 Tf
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[(not)-268.1(at)-264.7(all)-261.9(to)-268.6(3)]TJ
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5.5262 0 TD
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[(nearly)-261.4(every)-270.6(day\),)-265.2(and)-260.2(it)-266.3(can)]TJ
-15.175 -1.1065 TD
[(have)-262.1(a)-254.8(score)-259.1(range)-257.9(of)-260.9(027.)-253.9(Cutoffs)-258.3(of)-254.5(5,)-261.7(10,)-254.9(and)-253.9(15)-258.3(indicate)-262(mild,)]TJ
0 -1.1128 TD
[(moderate,)-319.9(and)-317.1(moderately)-320(severe)-317.9(to)-319.2(severe)-317.9(depressive)-321.2(symptoms,)]TJ
T*
(respectively.)Tj
6.7246 0 0 5.9768 105.5055 134.7024 Tm
(42)Tj
8.9663 0 0 8.9663 114.633 130.7338 Tm
[(The)-266.3(score)-265.4(was)-264.7(analyzed)-262.7(as)-268.2(an)-260.7(ordinal)-262.6(variable)-266.9(with)]TJ
-6.1206 -1.1128 TD
[(four)-281.5(levels:)-286.6(none,)-275.3(mild,)-284.4(moderate,)-282(and)-279.2(moderately)-282.1(severe/severe.)]TJ
/F2 1 Tf
1.1128 -2.6367 TD
[(Generalized)-828.2(Anxiety)-828.3(Disorder)-826.1(7-item)-822.4(scale)-826.8(\(GAD-7\).)]TJ
/F4 1 Tf
-1.1128 -1.1128 TD
(GAD-7)Tj
6.7246 0 0 5.9768 86.57 91.1621 Tm
(43)Tj
8.9663 0 0 8.9663 96.4913 87.137 Tm
[(measures)-359.6(severity)-360.5(of)-355.7(anxiety.)-353.8(It)-359.7(comprises)-360.7(seven)-357.7(items)]TJ
-4.0972 -1.1065 TD
[(that)-223.5(can)-218.3(be)-222.7(answered)-219.1(from)-221.8(0)]TJ
/F7 1 Tf
11.3433 0 TD
(=)Tj
/F4 1 Tf
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[(not)-217.5(at)-220.4(all)-224(to)-218(3)]TJ
/F7 1 Tf
5.3429 0 TD
(=)Tj
/F4 1 Tf
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[(nearly)-223.5(every)-220(day,)-218.9(and)]TJ
-18.1278 -1.1128 TD
[(it)-335.9(can)-332.2(have)-331.7(a)-330.7(score)-335(range)-333.8(of)-330.4(021.)-329.8(Cutoffs)-334.2(5,)-331.2(10,)-330.7(and)-329.7(15)-334.1(indicate)]TJ
T*
[(mild,)-550(moderate,)-553.9(and)-544.7(severe)-551.9(anxiety,)-549.8(respectively.)]TJ
6.7246 0 0 5.9768 249.3354 61.2283 Tm
(43)Tj
8.9663 0 0 8.9663 261.0141 57.2598 Tm
[(The)-544.5(score)]TJ
5.5578 74.5598 TD
[(was)-334.2(analyzed)-332.2(as)-331.4(an)-336.6(ordinal)-332.1(variable)-330.1(with)-338.2(four)-332(levels:)-330.8(none,)-332.2(mild,)]TJ
0 -1.1128 TD
[(moderate,)-282(and)-279.2(severe.)]TJ
/F2 1 Tf
1.1128 -2.5545 TD
[(Post-Traumatic)-732(Stress)-727.8(Disorder)-731.3(\(PTSD\))-735.6(Checklist)-734.8(for)]TJ
-1.1128 -1.2203 TD
[(DSM-5)-476.8(\(PCL-5\).)]TJ
/F4 1 Tf
6.7246 0 0 5.9768 385.7385 685.9274 Tm
(44)Tj
8.9663 0 0 8.9663 396.2834 681.9589 Tm
[(PCL-5)-426.9(measures)-429.2(symptoms)-426.9(of)-425.3(PTSD)-428.3(ac-)]TJ
-9.5286 -1.1128 TD
[(cording)-391.3(to)-395.1(DSM-5)-394.8(criteria.)]TJ
6.7246 0 0 5.9768 410.5133 675.9495 Tm
(45)Tj
8.9663 0 0 8.9663 420.7747 671.981 Tm
[(It)-397.7(consists)-395.8(of)-393.7(20)-397.4(items)-392.1(that)-394.2(can)-395.4(be)]TJ
-12.2601 -1.1128 TD
[(answered)-200.1(with)-205.4(0)]TJ
/F7 1 Tf
6.6264 0 TD
(=)Tj
/F4 1 Tf
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[(not)-198.6(at)-201.5(all)-198.7(to)-199.1(5)]TJ
/F7 1 Tf
5.267 0 TD
(=)Tj
/F4 1 Tf
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[(extremely,)-203.3(and)-197(it)-203.1(can)-199.4(have)-198.9(a)-204.3(score)]TJ
-13.335 -1.1128 TD
[(range)-251.6(of)-254.5(080.)-253.9(A)-249.4(score)]TJ
/F7 1 Tf
9.4085 0 TD
()Tj
/F4 1 Tf
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[(33)-251.9(was)-252(considered)-256.8(indicative)-258.7(of)-248.2(clinically)]TJ
-9.9586 -1.1065 TD
[(relevant)-279.6(PSTD.)]TJ
6.7246 0 0 5.9768 366.4629 646.0723 Tm
(46,47)Tj
/F8 1 Tf
8.9663 0 0 8.9663 310.8472 619.1431 Tm
[(Health-related)-336.2(quality)-332.7(of)-336.7(life)-330.7(\(HRQoL\))-337.9(measures)]TJ
0 -1.2203 TD
[(at)-330.4(6)-333.2(months)]TJ
/F2 1 Tf
1.1128 -1.8336 TD
[(Quality)-363(of)-362(Life)-369.8(after)-359.4(Brain)-366.2(Injury-Overall)-368.3(Scale)-363.6(\(QOLIBRI-)]TJ
-1.1128 -1.2203 TD
(OS\).)Tj
/F4 1 Tf
3.0603 0 TD
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[(The)-514.8(Q)2.8(OLIBRI-OS)]TJ
6.7246 0 0 5.9768 410.3999 584.7872 Tm
.0311 Tc
(48)Tj
8.9663 0 0 8.9663 422.192 580.8187 Tm
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T*
.0245 Tc
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16.996 0 TD
0 Tc
(<)Tj
/F4 1 Tf
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[(52)-563.2(on)-563.2(QOLIBRI-OS)]TJ
-17.5714 -1.1128 TD
.0247 Tc
[(was)-336.4(c)3.8(onsidered)-335.2(indicative)-337.6(of)-331.5(impa)]TJ
14.745 0 TD
.0245 Tc
[(ired)-335.4(disease-specic)-337.8(quality)]TJ
-14.745 -1.1128 TD
.0249 Tc
[(of)-274.4(life.)]TJ
6.7246 0 0 5.9768 336.5857 535.0109 Tm
.0396 Tc
[(37)8.5(,)11.4(4)0(9)]TJ
/F2 1 Tf
8.9663 0 0 8.9663 320.8251 508.0818 Tm
-.0203 Tc
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/F4 1 Tf
21.3651 0 TD
0 Tc
(SF-12v2)Tj
6.7246 0 0 5.9768 543.1747 512.0503 Tm
(50)Tj
8.9663 0 0 8.9663 310.8472 498.1038 Tm
[(with)-610.1(12)-612.3(items)-619.7(and)-608(SF-36v2)-616(with)-610.1(36)-612.3(items)-619.7(are)-613(self-reported)]TJ
0 -1.1065 TD
[(and)-500.5(generic)-497.3(measures)-505.1(of)-494.8(HRQoL.)-498.5(The)-500.3(results)-498.9(can)-502.9(be)-500.9(summa-)]TJ
0 -1.1128 TD
[(rized)-306.2(as)-306.1(mental)-304.3(and)-304.5(physical)-307.3(component)-305.2(scores)-310.4(ranging)-302.8(from)-310.3(0)-303(t)0(o)]TJ
T*
[(100.)-317.6(Mental)-326.8(and)-323.4(physical)-320(component)-324.1(scores)-323(were)-324.9(based)-319.7(on)-321.5(a)-324.4(SF-)]TJ
T*
[(12v2)-345.8(score,)-344.2(and)-348.7(when)-351.5(there)-344.1(was)-346.9(no)-346.8(available)-352.5(SF-12v2)-344.1(score,)-350.5(the)]TJ
0 -1.1065 TD
[(score)-499.4(was)-505(derived)-501.2(using)-502.3(SF-36v2)-495.9(\(w)14(h)13.1(e)0(n)-482(a)0(v)17.5(a)0(i)19.8(l)0(a)19.8(b)13.1(le)13.5(\).)]TJ
6.7246 0 0 5.9768 506.6644 452.296 Tm
(37)Tj
8.9663 0 0 8.9663 517.7195 448.3274 Tm
[(Ap)23(pr)17.3(o)13.1(x)0(i)15.9(-)]TJ
-23.0723 -1.1128 TD
[(ma)20.3(te)19.8(ly)-256(3)13.1(%)-260.9(of)-254.5(q)13.1(u)0(e)17.5(s)0(t)21.1(i)0(o)15.9(n)13.1(na)17.5(ir)19.6(es)-255.5(we)20.5(re)-250.6(l)17.3(le)19.8(d)-265.1(b)13.1(y)-265.1(a)-261.2(p)13.1(r)0(o)17.3(x)13.1(y)-265.1(a)0(l)19.8(o)0(n)19.9(e)0(,)-251.4(a)0(n)17.5(d)-265.1(1)13.1(0)0(%)]TJ
T*
[(b)13.1(y)-391.5(a)-387.6(p)0(a)17.5(t)0(i)18.2(e)0(n)23.9(t)-389.2(an)17.5(d)-385.2(p)0(r)17.3(o)0(x)20(y)-391.5(t)15.4(o)0(g)19.9(e)0(t)13.5(h)13.1(er)21.2(.)-388.6(M)0(e)16.8(n)0(t)22.3(a)0(l)-384.8(a)0(n)23.9(d)-391.5(p)13.1(h)0(y)19.9(s)0(i)14.7(c)0(a)21.4(l)-389.2(co)17.5(mp)22.7(on)20(en)17.5(t)]TJ
T*
[(sc)22.7(or)17.3(es)]TJ
/F7 1 Tf
2.9085 0 TD
(<)Tj
/F4 1 Tf
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[(40)-454.3(we)14.2(re)-453(co)17.5(n)13.1(s)0(i)21.1(d)0(e)17.5(r)0(e)21.2(d)-467.4(in)22.3(di)22.2(ca)15.1(ti)18.2(v)13.1(e)-463.5(fo)17.3(r)-463.7(i)0(m)18.7(p)13.1(ai)19.8(re)14.9(d)-461.1(m)0(e)20.3(n)0(t)15.9(a)0(l)-448.1(a)0(n)17.5(d)]TJ
-3.6167 -1.1065 TD
[(p)13.1(h)0(y)19.9(s)0(i)21.1(c)0(a)15.1(l)-269.1(HR)18.2(Qo)16.6(L)13.3(,)-268.5(re)14.9(sp)18.8(ec)21.4(ti)18.2(v)13.1(e)0(l)13.5(y)13.1(.)]TJ
6.7246 0 0 5.9768 420.2644 412.4408 Tm
[(37)22(,4)25(9)]TJ
/F8 1 Tf
8.9663 0 0 8.9663 310.8472 385.5117 Tm
[(Statistical)-336.1(analysis)]TJ
/F2 1 Tf
1.1128 -1.8273 TD
[(Descriptive)-380.9(statistics.)]TJ
/F4 1 Tf
10.4202 0 TD
[(Descriptive)-330.9(statistics)-333.4(for)-326.2(TBI)-328.1(charac-)]TJ
-11.533 -1.1128 TD
[(teristics,)-498.6(and)-494.1(treatment,)-504.5(and)-494.1(outcome)-495.8(variables)-501.6(were)-495.7(presented)]TJ
T*
[(separately)-351.7(for)-357.8(men)-352.2(and)-348.7(women)-354.6(using)-356.9(percentages)-356(for)-351.5(categorical)]TJ
T*
[(variables)-596.4(and)-589(median)-597.5(with)-591.1(interquartile)-601.6(range)-593(for)-591.8(continuous)]TJ
0 -1.1065 TD
[(outcomes.)-588(Differences)-596(were)-584.2(tested)-592.8(using)-590.8(non-parametric)-591.3(tests)]TJ
0 -1.1128 TD
[(\(e.g.,)-486.5(chi-square)-499.7(and)-487.8(Mann-Whitney)-492.8(U)-489.7(test\))-492.3(\(Table)-495.2(1;)-489.9(Supple-)]TJ
T*
[(mentary)-428.9(Table)-423.5(S1\).)-432.6(All)-427.2(analyses)-427.1(were)-426.1(performed)-429.1(separately)-433.9(for)]TJ
T*
[(mTBI)-280.6(and)-279.2(moderate/severe)-284.4(TBI.)]TJ
/F2 1 Tf
1.1128 -2.5545 TD
[(Mixed)-417.9(effects)-423.1(regression)-420.7(analyses.)]TJ
/F4 1 Tf
16.7115 0 TD
.018 Tc
[(The)-369.6(a)3.4(ssociation)-367.2(w)-3.8(ith)]TJ
-17.8243 -1.1128 TD
.0178 Tc
[(mult)-4.7(iple)-331.9(t)-4.7(r)3(eatment)-333.5(characteri)-4.7(s)]TJ
12.6774 0 TD
.0184 Tc
[(tics)-330.1(a)-2.5(nd)-328.9(outcomes)-330.1(f)-2.7(ollowing)-328.9(TBI)]TJ
-12.6774 -1.1065 TD
.0174 Tc
[(was)-280.5(a)2.8(nalyzed)-279.3(w)-4.4(ith)-279.3(univari)-5.1(able)-281.7(and)-273(m)-4.6(ulti)-5.1(-vari)-5.1(a)2.8(ble)-281.7(m)1.7(i)-5.1(x)-1.1(ed)-279.3(effects)]TJ
0 -1.1128 TD
.0184 Tc
[(regression)-278.3(analyses)-279.5(with)-278.3(a)-274.4(r)-2.7(andom)]TJ
14.7071 0 TD
.0186 Tc
[(intercep)6.4(t)-282.1(f)3.8(or)-280.7(study)-278.1(center.)-281.5(I)3.8(n)]TJ
-14.7071 -1.1128 TD
[(multi-v)6.3(a)-2.4(riable)-552.5(analys)5.2(es,)-553.5(w)3(e)-558.8(a)3.9(djusted)-556.4(f)3.7(or)-552.7(age,)-553.5(baseline)-552.5(GCS)]TJ
0 -1.1065 TD
.018 Tc
[(score,)-345.3(pup)5.8(illary)-341.9(reac)]TJ
8.6877 0 TD
.0186 Tc
[(tivity,)-344.7(h).1(y)6.5(potension)-341.3(and)-341.3(h)6.4(ypoxia)-343.7(b).1(efore)-337.4(a)-2.3(r-)]TJ
-8.6877 -1.1128 TD
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[(rival/at)-395.6(admission,)-395(CT)-397.7(ab)6.7(normali)]TJ
14.2392 0 TD
.018 Tc
[(ties)-400(\()3.2(C)-5.2(T)-398.6(Marshall)-402.8(Cl)-4.5(assica-)]TJ
-14.2392 -1.1128 TD
.0183 Tc
[(tion\),)-635.9(t)2.1(raumatic)-641.2(sub)6.1(a)-2.6(rachnoid)-638.8(h)]TJ
14.2076 0 TD
.0188 Tc
[(emorrhage)-640.7(\()-2.3(tSAH\),)-635.4(ep)6.6(idural)]TJ
-14.2076 -1.1128 TD
.0184 Tc
[(hematoma,)-332.3(I)-2.7(njury)-335.2(S)1.3(everity)-335.2(Score)-337.6(\()]TJ
14.7071 0 TD
.0195 Tc
[(ISS\),)-331.2(p)1(re)4.9(-injury)-334.1(m)3.8(edical)-331.8(sit-)]TJ
-14.7071 -1.1065 TD
[(ua)4.8(tion)-353.2(\(A)3.9(mer)4.6(i)3.2(can)-353.2(Society)-359.5(o).9(f)-355.8(A)3.9(ne)]TJ
14.2266 0 TD
.0184 Tc
[(sthes)5.1(i)-4.1(ologists)-361.7(P)1.3(hys)5.1(ical)-358.2(Status)]TJ
-14.2266 -1.1128 TD
[([ASA)-414.3(PS])-413.6(C)1.6(lassication\),)-414.4(p)0(re-inj)]TJ
14.2455 0 TD
.018 Tc
[(ury)-417.8(p)-.5(sychiatric)-420.2(disorder,)-421.2(a)3.4(nd)]TJ
-14.2455 -1.1128 TD
.0185 Tc
[(cause)-805.4(o)0(f)-811.9(i)2.3(njury)-803(\()-2.6(fall/motor)-805.6(ve)]TJ
14.4605 0 TD
.0203 Tc
[(h)8.1(i)-2.2(c)5.7(l)-2.2(e)-803.6(acc)5.7(id)8.1(ent)-805.2([)-.8(MV)4.8(A])5.5(/vio-)]TJ
-14.4605 -1.1128 TD
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[(lence/oth)6.1(e)-2.6(r\),)-212.2(w)-3.5(hich)-215.2(represent)-212.9(i)]TJ
12.6016 0 TD
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[(mportan)5.5(t)-219.8(predictors)-216.9(of)-212(outcome)-218.2(in)]TJ
-12.6016 -1.1065 TD
.0186 Tc
[(TBI)-230.1(a)4(nd/or)-230.1(can)-227.5(b).1(e)-229.9(a)4(ssoci)]TJ
10.2368 0 TD
.019 Tc
[(ated)-227.1(with)-227.1(s)5.7(e)-1.9(x/gender.)]TJ
6.7246 0 0 5.9768 481.9463 150.9165 Tm
.0223 Tc
[(3)-8.8(,)2.5(46)-8.8(,51)-8.8(53)]TJ
8.9663 0 0 8.9663 515.962 146.948 Tm
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[(Ana)-4(l).7(yses)]TJ
-22.8763 -1.1128 TD
.0186 Tc
[(of)-293.3(pre-hos)5.3(pital)-294.8(a)4(nd)-297.1(early)-297.1(hos)5.3(pita)]TJ
13.6828 0 TD
.0205 Tc
[(l)-292.9(m)4.8(ea)5.9(sure)5.9(s)-296.3(\()5.7(seco)8.3(ndary)-288.8(re)5.9(fer)5.7(r)-.6(a)5.9(l)-2(,)]TJ
-13.6828 -1.1128 TD
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[(time)-337.5(t)2.3(o)-335.1(s)-1.2(tudy)-335.1(center,)-332.2(p)0(re-ho)6.3(s)-1.2(pi)]TJ
13.0505 0 TD
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[(tal)-339.5(i)1.9(ntubatio)5.9(n)-.4(,)-338.9(time)-337.9(t)1.9(o)-335.5(C)1.2(T\))-338.1(were)]TJ
-13.0505 -1.1128 TD
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[(not)-319.4(adjusted)-321.7(for)-324.4(C)2.3(T)-327.9(M)6.4(ars)5.9(h).7(all)-325.8(C)2.3(la)4.6(ssication,)-325.2(tSah,)-325.2(a)-1.7(n)7(d)-328.1(ep)7(idur)4.4(al)]TJ
0 -1.1065 TD
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(hematoma.)Tj
1.1128 -1.1128 TD
0 Tc
[(The)-487.6(multi-variable)-497.2(regression)-492.1(analyses)-496.6(were)-489.3(performed)-492.3(in)-489.9(a)]TJ
-1.1128 -1.1128 TD
[(completed)-495(data)-500.1(set,)-495.9(in)-489.9(which)-500.5(missing)-491.1(values)-500.3(in)-496.2(potential)-497.1(con-)]TJ
0 -1.1065 TD
[(founders)-447.5(were)-451.4(imputed)-453.2(based)-452.5(on)-448(an)-450.4(imputation)-453.4(model)-450.1(with)-445.7(all)]TJ
0 -1.1128 TD
[(baseline)-297.1(characteristics,)-305.6(all)-299.9(outcomes,)-297.1(and)-298.1(auxiliary)-299.6(variables)-299.2(\(so-)]TJ
T*
[(ciodemographic)-541.8(variables,)-548.7(other)-544(indicators)-546.9(of)-539.1(medical)-546.5(history,)]TJ
/F1 1 Tf
-28.0042 77.228 TD
[(DIFFERENCES)-340.2(BETWEEN)-341.6(MEN)-331.1(AND)-337.2(WOMEN)-335.6(AFTER)-331(TBI)-26802.2(3)]TJ
ET
endstream
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0 -1.1128 TD
[(ues)-425.8(\(Table)-425.7(1\))-418.9(ranged)-428.1(from)]TJ
/F7 1 Tf
11.5836 0 TD
(<)Tj
/F4 1 Tf
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[(1%)-424.8(\(age,)-419.4(GCS)-428.8(score,)-420.1(ISS\))-424.1(to)-426.7(16%)]TJ
-12.1337 -1.1065 TD
[(\()-84.3(Marshall)-696.3(CT)-699.1(for)-692.9(moderate/severe\).)-706.7(Further,)-692.6(when)-699.3(the)-694.2(out-)]TJ
0 -1.1128 TD
[(come)-417.4(GOSE)-420.4(was)-416.4(assessed)-425.4(outside)-419.2(the)-416(time)-416.7(window)-418.7(\(range)-418.1(58)]TJ
T*
[(months\),)-371.3(it)-367.5(was)-372.2(imputed)-364.7(based)-376.6(on)-365.8(GOSE)-369.8(measurements)-374(at)-365.9(other)]TJ
T*
(time-points.)Tj
6.7246 0 0 5.9768 105.2787 220.7054 Tm
(37)Tj
8.9663 0 0 8.9663 114.5197 216.6803 Tm
[(Other)-281.8(outcome)-280.9(variables)-280.3(were)-287(not)-280.8(imputed.)]TJ
-4.7422 -1.1065 TD
[(Logistic)-473.1(mixed)-475.4(effects)-475.8(regression)-473.1(models)-476.1(were)-470.4(tted)-474.5(for)-471.6(di-)]TJ
-1.1128 -1.1128 TD
[(chotomized)-494.5(outcomes)-496.5(\(e.g.,)-499.2(treatment)-495.3(variables)-495.2(and)-494.1(mortality\),)]TJ
T*
[(whereas)-403(ordinal)-395.3(mixed)-399.6(effects)-399.9(regression)-397.3(models)-400.2(were)-394.5(tted)-398.6(for)]TJ
T*
[(ordinal)-401.7(outcomes)-395.4(\(GOSE,)-400.1(depression)-401(and)-399.3(anxiety)-401.5(severity\).)-403.5(The)]TJ
0 -1.1065 TD
[(results)-404(were)-400.8(presented)-396.4(in)-401.4(forest)-401.9(plots)-398.8(of)-393.6(ORs)-399.8(for)-402.1(women)-398.8(versus)]TJ
0 -1.1128 TD
[(men.)-348.8(For)-353.8(mTBI,)-353.1(forest)-351.3(plots)-348.2(were)-356.6(also)-353.4(stratied)-350(by)-353.1(different)-351.4(age)]TJ
T*
[(groups:)-339.5(1645)-332.7(years,)-344.2(4565)-332.7(years,)-337.9(and)-342.4(65)-334.1(years)-341.3(and)-336.1(older)-335.4(\(when)]TJ
0 -1.1065 TD
[(there)-603.4(were)]TJ
/F7 1 Tf
5.1595 0 TD
()Tj
/F4 1 Tf
.5564 0 TD
[(100)-599.2(outcome)-603.3(events)-607.8(in)-597.4(logistic)-603.8(regression\).)-610.9(For)]TJ
-5.7159 -1.1128 TD
[(moderate/severe)-341.3(TBI,)-331.1(stratied)-337.3(plots)-329.3(were)-337.6(only)-330.9(shown)-337.2(for)-332.5(GOSE)]TJ
T*
[(because)-285.6(of)-279.8(smaller)-282.3(subsamples.)]TJ
1.1128 -1.1128 TD
[(To)-390.9(check)-396.8(the)-397(sensitivity)-392.6(of)-393.6(the)-397(results)-391.4(to)-395.1(imputation)-396.5(of)-393.6(miss-)]TJ
-1.1128 -1.1065 TD
[(ing)-622.2(values,)-623.4(and)-626.9(dichotomization)-624.2(of)-621.3(continuous)-626.4(6-month)-620.1(out-)]TJ
0 -1.1128 TD
[(comes,)-180.7(we)-181.8(performed)-188.8(complete-case)-181.6(and)-184.3(linear)-183.3(regression)-182.3(analyses,)]TJ
T*
[(respectively)-285.2(\(Supplementary)-281.3(Tables)-285.1(S2)-275.8(and)-285.5(S3\).)]TJ
1.1128 -1.1128 TD
[(Analyses)-409(were)-413.5(carried)-417.7(out)-407.2(in)-414(R)]TJ
6.7246 0 0 5.9768 190.2047 71.2629 Tm
(54)Tj
8.9663 0 0 8.9663 200.6362 67.2378 Tm
[(\(version)-407.3(5.3\))-415(using)]TJ
/F10 1 Tf
8.2577 0 TD
(lme4)Tj
/F4 1 Tf
1.9475 0 TD
(,)Tj
6.7246 0 0 5.9768 294.4062 71.2629 Tm
(55)Tj
/F10 1 Tf
8.9663 0 0 8.9663 62.022 57.3165 Tm
(ordinal)Tj
/F4 1 Tf
2.9465 0 TD
(,)Tj
6.7246 0 0 5.9768 90.7086 61.285 Tm
(56)Tj
/F10 1 Tf
8.9663 0 0 8.9663 99.9496 57.3165 Tm
(mice)Tj
/F4 1 Tf
1.8969 0 TD
(,)Tj
6.7246 0 0 5.9768 119.1685 61.285 Tm
(57)Tj
/F10 1 Tf
8.9663 0 0 8.9663 128.4094 57.3165 Tm
(tableone)Tj
/F4 1 Tf
3.4586 0 TD
(,)Tj
6.7246 0 0 5.9768 161.6881 61.285 Tm
(58)Tj
8.9663 0 0 8.9663 170.9291 57.3165 Tm
(and)Tj
/F10 1 Tf
1.7262 0 TD
(forestplot)Tj
/F4 1 Tf
6.7246 0 0 5.9768 220.8755 61.285 Tm
(59)Tj
8.9663 0 0 8.9663 230.1165 57.3165 Tm
(packages.)Tj
/F1 1 Tf
9.2504 23.3315 TD
(Results)Tj
/F8 1 Tf
0 -1.8336 TD
[(Patient)-337.7(characteristics)-336.6(in)-330.2(men)-339.2(and)-329.4(women)]TJ
0 -1.2203 TD
[(in)-336.5(the)-334.8(CENTER-TBI)-335.3(study)]TJ
/F4 1 Tf
1.1128 -1.9475 TD
[(The)-386.5(study)-382.1(included)-382(2862)-383.7(adults)-381.8(\(36%)-382.1(women\))-388.3(categorized)-384.1(as)]TJ
-1.1128 -1.2203 TD
[(having)-205.8(mTBI,)-201.3(and)-203.3(1333)-200.4(adults)-198.4(\(26%)-205.1(women\))-198.6(categorized)-207.1(as)-198.6(having)]TJ
T*
[(moderate)-285.4(to)-281.3(severe)-280(TBI)-283.9(\(Table)-280.2(1\).)]TJ
1.1128 -1.2266 TD
[(Men)-513.8(were)-508.3(younger)-507.4(than)-510.3(women)-512.6(when)-509.6(they)-510.3(suffered)-509.4(a)-514.1(TBI)]TJ
-1.1128 -1.2203 TD
(\()Tj
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(p)Tj
/F7 1 Tf
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(<)Tj
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[(0.001\).)-296.9(Falls)-292.3(were)-299.6(the)-295.8(most)-297.6(common)-297.4(cause)-303.2(of)-292.5(mTBI)-299.6(for)-294.6(both)]TJ
-1.8906 -1.2203 TD
[(men)-289(and)-285.5(women,)-287.9(but)-287.1(the)-289.5(proportion)-286.6(of)-286.2(falls)-290(was)-283.7(higher)-290.6(in)-287.6(women)]TJ
0 -1.2266 TD
(\()Tj
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(p)Tj
/F7 1 Tf
.6639 0 TD
(<)Tj
/F4 1 Tf
.7208 0 TD
[(0.001\).)-284.2(The)-285.3(most)-285(frequent)-288.4(cause)-290.5(of)-286.2(moderate/severe)-290.7(TBI)-290.2(was)]TJ
-1.8906 -1.2203 TD
[(an)-197.4(MVA)-189.2(in)-192.7(men)-194.2(and)-197(women,)-193.1(but)-192.2(women)-190.2(had)-190.6(more)-196.3(moderate/severe)]TJ
T*
[(TBIs)-474.3(due)-462.5(to)-470.9(falls,)-470(and)-468.8(men)-466.1(due)-468.8(to)-464.6(violence)-473(and)-468.8(other)-468.2(reasons)]TJ
T*
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(p)Tj
/F7 1 Tf
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(<)Tj
/F4 1 Tf
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[(0.05\).)-227.8(Men)-229.3(with)-230.7(mTBI)-230(had)-228.6(higher)-227.4(ISS)-225.9(\()]TJ
/F10 1 Tf
15.8895 0 TD
(p)Tj
/F7 1 Tf
.6639 0 TD
(<)Tj
/F4 1 Tf
.7208 0 TD
[(0.001\),)-227.3(lower)-231.2(GCS)]TJ
-19.1647 -1.2266 TD
[(score)-531(\()]TJ
/F10 1 Tf
3.1425 0 TD
(p)Tj
/F7 1 Tf
.6639 0 TD
(<)Tj
/F4 1 Tf
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[(0.05\),)-518.6(and)-525.8(higher)-524.6(percentage)-526(of)-526.4(epidural)-523.7(hematoma)]TJ
-4.5272 -1.2203 TD
(\()Tj
/F10 1 Tf
.5058 0 TD
(p)Tj
/F7 1 Tf
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(<)Tj
/F4 1 Tf
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[(0.001\).)-372.7(There)-377.9(were)-381.8(more)-379.7(women)-379.9(who)-374.9(sustained)-377.6(a)-381.3(moderate)]TJ
-1.8906 -1.2203 TD
[(TBI,)-210.9(and)-203.3(men)-206.8(who)-210.5(sustained)-206.9(a)-204.3(severe)-210.4(TBI)-208(\()]TJ
/F10 1 Tf
17.2615 0 TD
(p)Tj
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(<)Tj
/F4 1 Tf
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[(0.05\).)-208.8(Women)-207.8(had)-203.3(a)]TJ
-18.6463 -1.2266 TD
[(higher)-556.2(proportion)-545.8(of)-551.7(psychiatric)-555.2(disorders)-553.4(prior)-550.6(to)-546.8(mTBI)-552.5(and)]TJ
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[(moderate/severe)-322.3(TBI)-309.2(\()]TJ
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9.32 0 TD
(p)Tj
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(<)Tj
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[(0.001\),)-309.5(and)-310.8(worse)-310.6(physical)-313.7(health)-313.4(prior)]TJ
-10.7047 -1.2203 TD
[(to)-281.3(mTBI)-280.6(\()]TJ
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(p)Tj
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(<)Tj
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[(0.001;)-276.4(Table)-284.4(1\).)]TJ
ET
62.022 720.113 490.167 .22681 re
f
62.022 326.608 490.167 .28348 re
f
210.898 700.724 163.389 .22675 re
f
381.43 700.724 170.759 .22675 re
f
62.022 673.001 490.167 .22675 re
f
BT
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8.9663 0 0 8.9663 78.5197 725.7825 Tm
(Table)Tj
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2.9971 0 TD
(1.)Tj
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/F10 1 Tf
17.7611 -2.3332 TD
[(Mild)-330.7(TBI)-13284(Moderate/severe)-343.4(TBI)]TJ
-5.7665 -2.8263 TD
[(Men)-3177.2(Women)]TJ
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10.7932 0 TD
(p)Tj
/F10 1 Tf
2.6177 1.1065 TD
(Missing)Tj
.8346 -1.1065 TD
[(\(%\))-3755.3(Men)-4113(Women)]TJ
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16.9201 0 TD
(p)Tj
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2.0866 1.1065 TD
(Missing)Tj
.8346 -1.1065 TD
(\(%\))Tj
-52.1703 -2.0992 TD
(N)Tj
/F4 1 Tf
17.976 0 TD
[(1842)-3564.2(1020)-12182.3(980)-5000(353)]TJ
-17.976 -1.1065 TD
[(GCS)-333.9(baseline)-335(\(%\))-20890.4(0.04)-2416.8(0)-15674(0.01)-2170.2(0)]TJ
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[(3-8)-336.3(\(%\))-14668.7(/)-5283.2(/)-11669.3(726)-333.7(\(74.1\))-2250.3(236)-333.6(\(66.9\))]TJ
T*
[(9-13)-335.8(\(%\))-14169.2(/)-5283.2(/)-11669.3(254)-333.7(\(25.9\))-2250.3(117)-333.6(\(33.1\))]TJ
T*
[(13)-15104.5(128)-333.6(\(6.9\))-2061.1(63)-334.1(\(6.2\))-12171.5(/)-6219(/)]TJ
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[(14)-15104.5(340)-333.6(\(18.5\))-1061.6(154)-333.7(\(15.1\))-11671.5(/)-6219(/)]TJ
0 -1.1128 TD
[(15)-14604.9(1374)-333.2(\(74.6\))-1061.6(803)-333.7(\(78.7\))-11671.5(/)-6219(/)]TJ
-.999 -1.4416 TD
[(Age)-15021.2(50)-334.1([32,)-332.9(65])-1145.6(58)-334.1([37,73])]TJ
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27.726 0 TD
(<)Tj
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[(0.001)-1916.8(0)-3236.8(4)0(7)-327.8([29,)-332.9(64])-2087.7(53)-334.1([30,69])-1522.7(0.02)-2170.2(0)]TJ
-28.2824 -1.1128 TD
[(Cause)-337.1(of)-330.4(injury)-336.5(\(%\))]TJ
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27.726 0 TD
(<)Tj
/F4 1 Tf
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[(0.001)-1916.8(1.6)-14924(0.01)-2170.2(3.6)]TJ
-27.2834 -1.1128 TD
[(Incidental)-339.5(fall)-10406(824)-333.6(\(45.7\))-1061.6(570)-333.7(\(56.4\))-9686.1(358)-333.7(\(37.9\))-2250.3(151)-333.6(\(44.3\))]TJ
T*
[(MVA)-13783.5(647)-333.6(\(35.8\))-1061.6(330)-333.7(\(32.7\))-9686.1(436)-333.7(\(46.2\))-2250.3(159)-333.6(\(46.6\))]TJ
0 -1.1065 TD
[(Other)-13825.5(173)-333.6(\(9.6\))-2061.1(70)-334.1(\(6.9\))-10685.6(85)-334.1(\(9.0\))-3249.8(17)-334.1(\(5.0\))]TJ
0 -1.1128 TD
[(Violence)-12483.5(161)-333.6(\(8.9\))-2061.1(40)-334.1(\(4.0\))-10685.6(65)-334.1(\(6.9\))-3249.8(14)-334.1(\(4.1\))]TJ
-.999 -1.4479 TD
[(Total)-336.6(ISS)-13036.2(13)-334.1([8,)-333.3(19])-1132.9(9.00)-305([4,)-314.4(16])]TJ
/F7 1 Tf
27.726 0 TD
(<)Tj
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[(0.00)-2416.8(0.8)-1924.1(34.00)-266.5([25,)-269.6(48])-797.8(33.00)-266.5([25,)-269.6(43])-797.8(0.28)-2170.2(0.8)]TJ
-28.2824 -1.1065 TD
[(Pupils)-333.7(reactivity)-337.2(Baseline)-339.8(\(%\))]TJ
6.7246 0 0 5.9768 171.9496 519.2502 Tm
(a)Tj
8.9663 0 0 8.9663 315.6093 515.2817 Tm
[(0.23)-2416.8(4.3)-14924(0.44)-2170.2(4.1)]TJ
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[(Both)-335.6(reactive)-10139.4(1699)-333.2(\(96.9\))-1061.6(964)-333.7(\(98.0\))-9686.1(691)-333.7(\(73.9\))-2250.3(242)-333.6(\(70.3\))]TJ
T*
[(One)-333(reactive)-11422.9(35)-334.1(\(2.0\))-2061.1(12)-334.1(\(1.2\))-10685.6(77)-334.1(\(8.2\))-3249.8(33)-334.1(\(9.6\))]TJ
0 -1.1065 TD
[(Both)-335.6(non-reactive)-9305.4(20)-334.1(\(1.1\))-2560.6(8)-334.6(\(0.8\))-10186.1(167)-333.7(\(17.9\))-2749.8(69)-334.1(\(20.1\))]TJ
-.999 -1.4479 TD
[(Hypoxia)-335.1(\(%\))-12322.9(42)-334.1(\(2.4\))-2061.1(15)-334.1(\(1.5\))-2118(0.17)-2416.8(3.9)-2651.2(164)-333.7(\(17.8\))-2749.8(50)-334.1(\(15.1\))-1523.2(0.29)-2170.2(6.2)]TJ
0 -1.1128 TD
[(Hypotension)-338.4(\(%\))-10653.6(47)-334.1(\(2.6\))-2061.1(24)-334.1(\(2.4\))-2118(0.84)-2416.8(3.0)-2651.2(159)-333.7(\(17.3\))-2749.8(43)-334.1(\(12.8\))-1523.2(0.07)-2170.2(6.0)]TJ
0 -1.1065 TD
[(Marshall)-335.9(CT)-332.3(Classication)-338.8(\(%\))]TJ
6.7246 0 0 5.9768 176.7684 456.4912 Tm
(a)Tj
8.9663 0 0 8.9663 315.6093 452.5227 Tm
[(0.09)-2416.8(9.8)-14924(0.36)-1670.7(16.4)]TJ
-28.2824 -1.1128 TD
[(No)-337.4(visible)-334.7(pathology)-8529.4(884)-333.6(\(53.3\))-1061.6(531)-333.7(\(57.5\))-10185.6(67)-334.1(\(8.2\))-3249.8(21)-334.1(\(7.1\))]TJ
T*
[(Cisterns)-338.7(present)-10593.8(615)-333.6(\(37.1\))-1061.6(321)-333.7(\(34.7\))-9686.1(339)-333.7(\(41.3\))-2250.3(116)-333.6(\(39.5\))]TJ
T*
[(Cisterns)-338.7(compressed)-9261.3(23)-334.1(\(1.4\))-2560.6(6)-334.6(\(0.6\))-10685.6(87)-334.1(\(10.6\))-2749.8(32)-334.1(\(10.9\))]TJ
0 -1.1065 TD
[(Midline)-334.2(shift)-12813.3(2)-334.6(\(0.1\))-2560.6(3)-334.6(\(0.3\))-10685.6(22)-334.1(\(2.7\))-3749.3(2)-334.6(\(0.7\))]TJ
0 -1.1128 TD
[(Evacuated)-337.9(and)-336.1(non-evacuated)-334.8(lesion)-2221.7(133)-333.6(\(8.0\))-2061.1(63)-334.1(\(6.8\))-10186.1(305)-333.7(\(37.1\))-2250.3(123)-333.6(\(41.8\))]TJ
T*
[(Subarachnoid)-335.4(hemorrhage)-339.9(\(%\))-4634.2(524)-333.6(\(30.9\))-1061.6(279)-333.7(\(29.5\))-1618(0.46)-2416.8(8.3)-2651.2(652)-333.7(\(76.5\))-2250.3(224)-333.6(\(72.0\))-1523.2(0.13)-1670.7(13.2)]TJ
0 -1.1065 TD
[(Epidural)-337.8(hematoma)-336.9(\(%\))-7289.9(159)-333.6(\(9.4\))-2061.1(46)-334.1(\(4.9\))]TJ
/F7 1 Tf
27.726 0 TD
(<)Tj
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[(0.00)-2416.8(7.9)-2651.2(144)-333.7(\(16.9\))-2749.8(51)-334.1(\(16.4\))-1523.2(0.91)-1670.7(13.0)]TJ
-28.2824 -1.1128 TD
[(Pre-injury)-334.4(psychiatric)-340.2(condition)-332.6(\(%\))-2345.3(210)-333.6(\(11.6\))-1061.6(183)-333.7(\(18.0\))]TJ
/F7 1 Tf
27.726 0 TD
(<)Tj
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[(0.00)-2416.8(1.0)-2651.2(120)-333.7(\(13.3\))-2749.8(64)-334.1(\(19.1\))-1523.2(0.01)-2170.2(7.1)]TJ
-28.2824 -1.1128 TD
[(Pre-injury)-334.4(physical)-339(health)-332.4(-)-337.2(ASA)-332.5(PS)-331.3(Classication)-338.8(\(%\))-5702.8(0.23)-2416.8(1.0)-14924(0.23)-2170.2(5.6)]TJ
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[(Healthy)-335.2(patients)-8973.7(1063)-333.2(\(58.5\))-1061.6(505)-333.7(\(49.8\))-9686.1(532)-333.7(\(57.5\))-2250.3(177)-333.6(\(53.2\))]TJ
0 -1.1065 TD
[(Mild)-335.6(systemic)-337.3(disease)-7085.6(567)-333.6(\(31.2\))-1061.6(388)-333.7(\(38.2\))-9686.1(283)-333.7(\(30.6\))-2250.3(122)-333.6(\(36.6\))]TJ
0 -1.1128 TD
[(Severe)-245.8(systemic)-248.8(disease/threat)-247.6(to)-243.3(life)-1301(188)-333.6(\(10.4\))-1061.6(122)-333.7(\(12.0\))-9686.1(110)-333.7(\(11.9\))-2749.8(34)-334.1(\(10.2\))]TJ
5.9774 0 0 5.3127 70.0157 318.3873 Tm
(a)Tj
7.9702 0 0 7.9702 72.6803 314.8157 Tm
[(Small)-325.4(subcategorie)10.5(s)-333.4(merged)-328.1(for)-327.8(regression)-327.6(analyses.)]TJ
-.3343 -1.1239 TD
[(ASA)-274(PS,)-282(America)11.2(n)-282.4(Society)-278.3(of)-276.7(Anesthesiolo)11(gists)-280.6(Physical)-277.4(Status;)-274.8(CT,)-276.7(computed)-276.3(tomogra)13(phy;)-281.8(GCS,)-275.2(Glasgow)-277.9(Coma)-273.4(Scale;)-276.5(ISS,)-283.3(Injury)-270.2(Severity)-279.6(Score;)]TJ
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[(MVA,)-331.2(motor)-322.2(vehicle)-333.5(acciden)10.3(t;)-334.3(TBI,)-327.9(traumatic)-327.6(brain)-329(injury.)]TJ
/F1 1 Tf
8.9663 0 0 8.9663 62.022 749.6502 Tm
(4)Tj
46.8781 0 TD
(MIKOLIC)Tj
3.7052 .2213 TD
()Tj
.8536 -.2213 TD
[(ET)-338.7(AL.)]TJ
ET
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59.754 673.001 490.167 .22675 re
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BT
/F6 1 Tf
8.9663 0 0 8.9663 134.9858 725.7825 Tm
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(Table)Tj
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(2.)Tj
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9.712 -2.3332 TD
[(Mild)-337(TBI)-13208.1(Moderate/severe)-343.4(TBI)]TJ
-5.248 -1.7135 TD
[(Men)-4808.5(Women)]TJ
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(p)Tj
/F10 1 Tf
5.5831 0 TD
[(Men)-4555.6(Women)]TJ
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13.531 0 TD
(p)Tj
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-53.2958 -2.0992 TD
(N)Tj
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20.0183 0 TD
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0 -1.1128 TD
[(Discharge)-336.4(home)-339.1(\(%\))-10685.3(459)-327.3(\(25.0\))-2699.2(343)-333.6(\(33.9\))]TJ
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33.0309 0 TD
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(0.001)Tj
-33.5873 -1.1128 TD
[(ICU)-337.9(admission)-334.4(\(%\))-11197.4(428)-327.3(\(23.3\))-2699.2(146)-333.6(\(14.4\))]TJ
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33.0309 0 TD
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[(0.001)-2694.5(687)-333.7(\(70.6\))-2692.9(233)-333.6(\(66.6\))-2692.9(0.181)]TJ
-33.5873 -1.1128 TD
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T*
[(Final)-335.4(discharge)-339.5(location)-335.5(\(%\),)-331.2(survivors)-17641.8(0.077)-16579.6(0.987)]TJ
1.0053 -1.1065 TD
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T*
[(Longer)-337(time)-334.5(to)-331.8(CT)-338.7(\(median\))-329.8(\(%\))-5608(823)-327.3(\(48.2\))-2699.2(509)-333.6(\(53.4\))-3249.3(0.012)-2694.5(438)-333.7(\(50.8\))-2692.9(152)-333.6(\(48.9\))-2692.9(0.616)]TJ
0 -1.1065 TD
[(ICP)-339.6(monitoring)-329.5(\(%\))-30355.8(539)-333.7(\(58.5\))-2692.9(180)-333.6(\(54.9\))-2692.9(0.288)]TJ
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T*
[(Extra-cranial)-339.2(surgery)-334.2(\(%\))-8731.5(218)-327.3(\(15.6\))-3198.8(87)-334.1(\(12.9\))-3249.3(0.123)-2694.5(288)-333.7(\(29.6\))-3192.4(86)-334.1(\(24.8\))-2692.9(0.099)]TJ
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ET
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420.92 0 0 301.153 94.507 125.008 cm
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BT
/F5 1 Tf
8.9663 0 0 8.9663 59.7543 108.2268 Tm
[(FIG.)-480.2(1.)]TJ
/F4 1 Tf
4.2553 0 TD
[(Forest)-480.1(plot)-474(with)-477.3(adjusted)-478.1(odds)-473.5(ratios)-479.2(\(ORs\))-473.5(for)-478(women)-474.7(with)-477.3(mild)-477.5(traumatic)-476.3(brain)-474.5(injury:)-479.1(care)-475.8(pathway)-476.6(and)-475.2(treatment)]TJ
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0 -1.1128 TD
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T*
[(\(ISS\),)-315.3(pre-injury)-310.6(medical)-318.9(situation)-312.5(\(ASA)-315.7(PS)-306(Classication\),)-318.6(pre-injury)-316.9(psychiatric)-314.9(disorder,)-309(and)-317.1(cause)-309.5(of)-317.8(injury.)-307.8(*Not)-315.2(adjusted)-313.6(for)-313.6(CT)]TJ
T*
[(Marshall)-266.4(Classication,)-259.5(tSAH,)-263.1(and)-260.2(epidural)-258.2(hematoma.)-263.9(ASA)-256.6(PS,)-264.7(American)-257.1(Society)-261(of)-260.9(Anesthesiologists)-265(Physical)-261.7(Status;)-257.4(CT,)-259.4(computed)]TJ
0 -1.1065 TD
[(tomography;)-340(ICU,)-334.5(intensive)-329.8(care)-336.7(unit;)-338.4(n/outcome,)-331.1(number)-334.4(of)-336.7(patients/number)-333.2(of)-336.7(patients)-336.7(with)-331.9(outcome.)]TJ
/F1 1 Tf
27.0621 -2.624 TD
(5)Tj
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